“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.
A handful of pistachios a day slightly lowers cholesterol, triglycerides, fasting blood glucose and systolic blood pressure; it does not cause weight gain, but it slowed down cyclists.
Endurance: in 19 cyclists, two weeks of pistachios (3 ounces, about 85 g per day), plus a dose taken before and during exercise, made a 75 km time trial 4.8% slower. Limitations: not a weight-loss food: no net effect on weight (−0.22 kg, non-significant) or waist circumference in a meta-analysis of 11 trials and 1,593 people; in a weight-loss program, 42 g per day resulted in the same weight loss as without pistachios. HDL does not change in a meta-analysis of 12 trials, nor does diastolic blood pressure, CRP or artery dilation in a meta-analysis of 13 trials. Glycated hemoglobin and fasting insulin: no clear improvement in a meta-analysis of 6 trials, contrary to another; in well-controlled diabetics, 4 weeks changed neither fasting blood glucose nor insulin. Small and short trials: from 10 to 100 participants, over 3 to 24 weeks, mainly in people with high cholesterol or blood glucose.
42 to 84 g per day (about 10 to 20% of calories), for 3 to 24 weeks in the trials.
In a crossover trial, eating pistachios modified the gut microbiota much more markedly than almonds, with more bacteria capable of producing butyrate.
A systematic review and meta-analysis of twelve randomized clinical trials examined the effects of pistachio consumption on lipid profiles in adults. The results show that pistachio consumption significantly decreases total cholesterol, LDL cholesterol, and triglycerides. These improvements in the lipid profile suggest that pistachios can be protective against cardiometabolic diseases.
Hadi A, Asbaghi O, Kazemi M, Haghighian HK, Pantovic A, Ghaedi E, Abolhasani Zadeh F. — Critical reviews in food science and nutrition (2023) — View the source study
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