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Dietary supplements · Pistachios
Pistachios, split open in their shells

Pistachios, split open in their shells

Kobi Schutz · CC BY-SA 3.0

Strong evidence24 studies
How we rate

“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.

Pistachios

A handful of pistachios a day slightly lowers cholesterol, triglycerides, fasting blood glucose and systolic blood pressure; it does not cause weight gain, but it slowed down cyclists.

HeartBlood sugar

Benefits

  • Slightly lowers cholesterol: −7.48 mg/dL of total cholesterol, −3.82 mg/dL of LDL and −11.19 mg/dL of triglycerides in a meta-analysis of 12 trials.
  • The effect is dose-dependent: with two servings per day (20% of calories), −11.6% of LDL and −8% of total cholesterol in 4 weeks; a single serving lowers the ratios to HDL by only 1 to 3%.
  • Lowers triglycerides during a diet: 88 mg/dL compared to 132 mg/dL after 12 weeks with 53 g of pistachios as a snack, instead of pretzels.
  • Slightly lowers fasting blood glucose and glycated hemoglobin (−0.14 points) in a meta-analysis of 11 trials; in type 2 diabetics, 25 g twice a day for 12 weeks lowered fasting blood glucose by 16 mg/dL and glycated hemoglobin by 0.4 points.
  • Blunts the blood sugar spike of a meal: with white bread, 56 g of pistachios bring the glycemic response down to 67.3% of that of bread alone, and 84 g down to 51.5%.
  • Slightly lowers systolic blood pressure: −2.12 mmHg in a meta-analysis of 13 trials (563 participants), −3.10 mmHg in another; diastolic blood pressure does not budge.
  • Does not cause weight gain: 42 or 70 g per day for 12 weeks changed neither weight nor waist circumference in 90 people with metabolic syndrome, nor did 44 g per day in 60 healthy women, who spontaneously ate less of other things.
  • Slightly improves artery flexibility: pulse wave velocity reduced in 3 months with 40 g of shelled pistachios per day in 60 adults with slightly high cholesterol.

Precautions

Endurance: in 19 cyclists, two weeks of pistachios (3 ounces, about 85 g per day), plus a dose taken before and during exercise, made a 75 km time trial 4.8% slower. Limitations: not a weight-loss food: no net effect on weight (−0.22 kg, non-significant) or waist circumference in a meta-analysis of 11 trials and 1,593 people; in a weight-loss program, 42 g per day resulted in the same weight loss as without pistachios. HDL does not change in a meta-analysis of 12 trials, nor does diastolic blood pressure, CRP or artery dilation in a meta-analysis of 13 trials. Glycated hemoglobin and fasting insulin: no clear improvement in a meta-analysis of 6 trials, contrary to another; in well-controlled diabetics, 4 weeks changed neither fasting blood glucose nor insulin. Small and short trials: from 10 to 100 participants, over 3 to 24 weeks, mainly in people with high cholesterol or blood glucose.

Recommended dosage

42 to 84 g per day (about 10 to 20% of calories), for 3 to 24 weeks in the trials.

How to take it

  • Quantity: 42 g per day (one serving) in several trials, up to 70 or 84 g; the effect on cholesterol is clearer with two servings than with one.
  • With a high-carbohydrate meal: 56 g of pistachios added to rice or pasta reduced the rise in blood glucose; eaten alone, they barely raise it.
  • As a snack: instead of pretzels or cookies in the afternoon, or in the mid-morning, with no weight gain in the trials.
  • Calories: pistachios provide about 5% less energy than the value usually calculated, with 22.6 kJ/g measured versus 23.7 kJ/g.
  • Duration: from 3 weeks (cholesterol) to 24 weeks (metabolic syndrome) in the trials.
  • For whom: most trials involve adults with high cholesterol, prediabetics, type 2 diabetics or people with metabolic syndrome.
  • Before exercise: do not use them as fuel for a long endurance workout; cyclists who ate them before and during a time trial were slower.

Did you know?

In a crossover trial, eating pistachios modified the gut microbiota much more markedly than almonds, with more bacteria capable of producing butyrate.

What the studies say

  • A systematic review and meta-analysis of twelve randomized clinical trials examined the effects of pistachio consumption on lipid profiles in adults. The results show that pistachio consumption significantly decreases total cholesterol, LDL cholesterol, and triglycerides. These improvements in the lipid profile suggest that pistachios can be protective against cardiometabolic diseases.

    Hadi A, Asbaghi O, Kazemi M, Haghighian HK, Pantovic A, Ghaedi E, Abolhasani Zadeh F. — Critical reviews in food science and nutrition (2023) — View the source study

For information only: not a substitute for medical advice. Dietary supplements are not a replacement for a varied, balanced diet. Learn more