“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.
In small trials, L-tyrosine limited the decline in memory and attention during stress situations: cold, sleep deprivation, military training. For sports, a meta-analysis of 8 studies found no effect on endurance.
Tolerance: in 30 healthy men, 1 to 4 g per day for 4 weeks did not alter any blood parameters, and mild adverse effects were just as frequent as with the placebo. Elderly individuals: in adults aged 60 to 75, tyrosine levels rose higher in the blood than in young people, and high doses decreased working memory. Limitations: endurance: in a meta-analysis of 8 studies, no effect on either time to exhaustion or time trials (moderate quality of evidence). Heat: the positive trial is isolated; four others found nothing, neither in cycling time trials among 7 and 8 trained men, nor in soccer players during intermittent exercise, nor on cognitive performance during a simulated military exercise. Strength: in 20 men, 150 mg per kilo improved neither treadmill endurance, power, nor strength after carrying a heavy load. Depression: in 65 patients, 100 mg per kilo per day for 4 weeks had no antidepressant effect. Small trials: ranging from 8 to 22 participants for most effects on memory, often in a single dose; a review issued only a weak recommendation for mental stress, and none for physical performance.
Trials: 100 to 150 mg per kilo in a single dose, 1 to 2 hours before the task or effort; 2 g per day for 5 days in cadets.
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In 17 adults aged 60 to 75, the higher the tyrosine dose (from 100 to 200 mg per kilo), the worse they performed on a working memory test: the opposite of the desired effect.
A systematic review and meta-analysis evaluated the effect of L-tyrosine on overall endurance performance in physically active individuals. Results indicate, with moderate quality of evidence, that tyrosine supplementation is ineffective for improving endurance performance, regardless of the task type.
Solon-Júnior LJF, Boullosa Alvarez DA, Martinez Gonzalez B, da Silva Machado DG, de Lima-Junior D, de Sousa Fortes L. — Journal of sports sciences (2023) — View the source study
For information only: not a substitute for medical advice. Dietary supplements are not a replacement for a varied, balanced diet. Learn more