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Dietary supplements · L-tyrosine
Pieces of Parmesan cheese on a black background

Pieces of Parmesan cheese on a black background

THOR · CC BY 2.0

Moderate evidence22 studies
How we rate

“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.

L-tyrosine

In small trials, L-tyrosine limited the decline in memory and attention during stress situations: cold, sleep deprivation, military training. For sports, a meta-analysis of 8 studies found no effect on endurance.

Cognition

Benefits

  • Memory in the cold: in 8 men exposed to 4 °C, 150 mg per kilo taken 2 hours prior restored the accuracy of a memory test to the level measured at 22 °C.
  • Sleep deprivation: after a sleepless night, 150 mg per kilo improved a psychomotor task and reduced errors in a vigilance task.
  • Military stress: in 21 cadets undergoing combat training, a beverage providing 2 g of tyrosine per day for 5 days improved a memory test and a visual tracking test, and lowered systolic blood pressure.
  • Intense noise: in 16 young adults, 100 mg per kilo improved two mental tasks sensitive to stress and lowered diastolic blood pressure.
  • Multitasking: in 20 adults, 150 mg per kilo taken 1 hour before made working memory more accurate when other tasks were performed at the same time, without changing anything for simple tasks.
  • Mental flexibility: in 22 adults, tyrosine reduced the cost of switching from one task to another compared to a placebo.
  • Cycling after mental fatigue: in 12 recreational cyclists, 300 mg per kilo increased pedaling time to exhaustion by 16 % (460 versus 399 seconds), with a perceived exertion that rose less quickly.
  • Heat: in 8 men cycling at 30 °C, 150 mg per kilo taken 1 hour before allowed them to last 80.3 minutes versus 69.2 minutes under placebo.

Precautions

Tolerance: in 30 healthy men, 1 to 4 g per day for 4 weeks did not alter any blood parameters, and mild adverse effects were just as frequent as with the placebo. Elderly individuals: in adults aged 60 to 75, tyrosine levels rose higher in the blood than in young people, and high doses decreased working memory. Limitations: endurance: in a meta-analysis of 8 studies, no effect on either time to exhaustion or time trials (moderate quality of evidence). Heat: the positive trial is isolated; four others found nothing, neither in cycling time trials among 7 and 8 trained men, nor in soccer players during intermittent exercise, nor on cognitive performance during a simulated military exercise. Strength: in 20 men, 150 mg per kilo improved neither treadmill endurance, power, nor strength after carrying a heavy load. Depression: in 65 patients, 100 mg per kilo per day for 4 weeks had no antidepressant effect. Small trials: ranging from 8 to 22 participants for most effects on memory, often in a single dose; a review issued only a weak recommendation for mental stress, and none for physical performance.

Recommended dosage

Trials: 100 to 150 mg per kilo in a single dose, 1 to 2 hours before the task or effort; 2 g per day for 5 days in cadets.

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How to take it

  • What it is for: the measured effects relate to memory and attention in a demanding situation (cold, lack of sleep, stress, multitasking); for sports, the meta-analysis finds nothing.
  • Dose: most trials give 150 mg per kilo in a single dose, 100 mg per kilo against noise, 300 mg per kilo in the trial on cyclists.
  • Timing: taken 1 hour before in the multitasking trial and the heat trial, 2 hours before in the cold trial.
  • Over multiple days: 2 g per day for 5 days in cadets; up to 4 g per day for 4 weeks well tolerated in 30 men.
  • After age 60: in 9 elderly individuals, 150 mg per kilo helped the body retain its heat in the cold, but in 17 adults aged 60 to 75, 100 to 200 mg per kilo impaired working memory, all the more so as the dose was high.
  • What does not work: 25 mg per kilo changed nothing in a cycling time trial among 9 cyclists; only carbohydrates improved it.

Did you know?

In 17 adults aged 60 to 75, the higher the tyrosine dose (from 100 to 200 mg per kilo), the worse they performed on a working memory test: the opposite of the desired effect.

What the studies say

  • A systematic review and meta-analysis evaluated the effect of L-tyrosine on overall endurance performance in physically active individuals. Results indicate, with moderate quality of evidence, that tyrosine supplementation is ineffective for improving endurance performance, regardless of the task type.

    Solon-Júnior LJF, Boullosa Alvarez DA, Martinez Gonzalez B, da Silva Machado DG, de Lima-Junior D, de Sousa Fortes L. — Journal of sports sciences (2023) — View the source study

For information only: not a substitute for medical advice. Dietary supplements are not a replacement for a varied, balanced diet. Learn more