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Dietary supplements · Chia seeds
Chia seeds in a small dish

Chia seeds in a small dish

Jubair Bin Iqbal · CC BY-SA 4.0

Strong evidence24 studies
How we rate

“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.

Chia seeds

Chia seeds lower blood pressure by a few mmHg and CRP in meta-analyses, and curb the blood sugar spike of a meal; nothing on weight, cholesterol or fasting blood glucose.

Heart

Benefits

  • Lowers blood pressure: −5.61 mmHg systolic and −7.49 mmHg diastolic in a meta-analysis of 8 trials (372 participants), −7.19 and −6.04 mmHg in another.
  • The effect is dose-dependent: each extra 10 g per day lowers systolic blood pressure by 2.20 mmHg in a dose-response meta-analysis of 10 publications.
  • In hypertensive individuals, 35 g of chia flour per day for 12 weeks brought average blood pressure down from 111.5 to 102.7 mmHg, including in those already treated.
  • In type 2 diabetics, about 37 g per day for 12 weeks lowered systolic blood pressure by 6.3 mmHg and CRP by 40% compared to wheat bran; 40 g per day for 12 weeks also lowered systolic blood pressure in another trial.
  • Slightly lowers CRP, a marker of inflammation: −0.64 mg/dl in a meta-analysis of 4 trials (210 participants), with no effect on IL-6 or TNF-α.
  • Blunts the blood sugar spike from a meal: up to 24 g baked in bread raises blood glucose less, all the more so as the dose is higher; chia performed better than flaxseed in another trial.
  • Slightly satiating in the moment: 7 or 14 g in a mid-morning yogurt reduced hunger and what 24 people ate at lunch.
  • When ground, they provide omega-3s: 25 g per day for 7 weeks increased blood ALA by 138% and EPA by 30% in 10 postmenopausal women.

Precautions

HDL: several studies find it slightly lower with chia, −4.09 mg/dl in a meta-analysis of 10 publications and −0.10 mmol/L in another; a trial in obese people also saw HDL drop. Blood pressure: in hypertensive individuals already on antihypertensives, blood pressure dropped further with 35 g of chia flour per day; if you are treated, talk to your doctor. Limitations: no effect on weight: +0.09 kg, non-significant, in a meta-analysis of 8 trials; a 6-month trial in dieting diabetics finds 1.9 kg lost versus 0.3 kg, but another in obese people finds nothing. Cholesterol does not change: neither triglycerides, nor total cholesterol, nor LDL in a meta-analysis in overweight people; another finds a drop in triglycerides and LDL only at high doses. Fasting blood glucose and glycated hemoglobin: no effect in a meta-analysis of 8 trials (362 participants). Low-quality evidence: the 2018 meta-analysis rates all evidence as low or very low quality, and no trials measure actual diseases, only markers.

Interacts with:Antihypertensives

Recommended dosage

25 to 40 g per day in trials lasting several weeks (7 weeks to 6 months), often ground.

How to take it

  • Quantity: 25 to 40 g per day in trials lasting several weeks; in a trial on dieting diabetics, 30 g per 1,000 kcal.
  • Ground rather than whole for omega-3s: when ground, 25 g per day increased ALA by 58% and EPA by 39%; whole, nothing changed.
  • Blood glucose response to a meal: whole or ground perform equally well, only the dose matters (7, 15 or 24 g baked in bread).
  • As a snack: 7 to 14 g in a mid-morning yogurt were enough to increase satiety slightly.
  • Duration: from 7 weeks to 6 months in trials; a meta-analysis does not find the effect on blood pressure to be stronger with a larger dose.
  • For whom: many trials involve individuals with hypertension, type 2 diabetes or overweight.
  • Before exercise: useless; chia oil drunk before a run to exhaustion did not prolong the running time of 24 runners.

Did you know?

When soaked, chia seeds form a gel about twenty times more viscous than that of flaxseed (49.9 vs 2.5 Pa·s), and they slowed the arrival of sugar into the blood to a greater extent.

What the studies say

  • This systematic review and dose-response meta-analysis of 8 randomized clinical trials explored the effects of chia seed consumption on blood pressure, body composition, and glycemic control. The results revealed a significant reduction in systolic and diastolic blood pressures. However, no significant effect was observed on body weight, body composition, or glycemic parameters such as fasting blood glucose and HbA1c.

    TaghipourSheshdeh F, Behzadi M, Bashiri S, Mohammadi-Sartang M. — Nutrition reviews (2025) — View the source study

For information only: not a substitute for medical advice. Dietary supplements are not a replacement for a varied, balanced diet. Learn more