“Strong” = several concordant meta-analyses or systematic reviews. “Moderate” = one synthesis, or several controlled trials. “Limited” = early trials only. The rating is about the quality of the studies, not about how useful the supplement is.
Soluble fiber that lowers total cholesterol and LDL in meta-analysis and provides slight relief for irritable bowel syndrome in its hydrolyzed form. It does not cause weight loss.
Stomach: abdominal pain, flatulence, diarrhea, and cramps are the most frequent adverse effects; 3% of participants stopped because of them in weight trials. Toddlers: EFSA considers guar safe as an additive for the general population, but asks to monitor abdominal discomfort in infants and young children. Medications: taken with a meal, guar gum did not prevent the decrease in absorption of trimethoprim; the authors advise taking this antibiotic between meals. Limits: weight: no difference with placebo in a meta-analysis of 11 trials; the authors consider that risks outweigh benefits for weight loss. Satiety: in 25 obese dieting women, 20 g per day did not increase the feeling of satiety. Blood pressure: in 141 overweight hypertensives, six months of guar did not lower it, unlike psyllium. Constipation: in 52 elderly nursing home residents, neither stool frequency nor shape changed (only laxative use decreased); mixed with inulin, no advantage over placebo in 60 constipated women. Triglycerides and HDL: no effect on average; triglycerides only drop at 20 g per day or more in diabetics.
5 g per day of partially hydrolyzed gum (transit, irritable bowel); more than 15 g per day for fasting blood glucose in diabetics.
Added for 10 days to an antibiotic, 5 g per day of hydrolyzed guar gum increased the eradication of small intestinal bacterial overgrowth from 62.1% to 87.1% of patients.
This meta-analysis of 11 studies examined the impact of guar gum consumption on the lipid profile in patients with type 2 diabetes. The results showed a significant reduction in total cholesterol and LDL cholesterol. A dose of ≥20 g/day of guar gum also led to a noticeable decrease in triglycerides, with no effect on HDL cholesterol.
Li J, Chen R, Chen Y, Zhu D, Wu Z, Chen F, Huang X, Ali Khan B, Al Hennawi HE, Albazee E, Prabahar K, Hou K. — Critical reviews in food science and nutrition (2023) — View the source study
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